The potential utility of Niclosamide has been demonstrated due to the drug’s ability to disrupt mitochondrial phosphorylation and affect multiple mechanisms. Medical treatments for diabetes, Parkinson’s, microorganisms, viruses and cancers could all potentially benefit from making use of this drug in new ways.
Diabetes
Approximately a third of Americans are affected by pre-diabetes and over one in ten have been diagnosed with diabetes. Researching therapies which could result in successful outcomes for this many individuals is sensible. Mice used in the study found a salt type of Niclosamide Ethanolamine improved their energy expenditure and lipid metabolism. Additionally, this drug was effective in lowering the high blood sugar experienced by mice on a high-fat diet.
Parkinson’s Disease (PD)
Mutations of Mitochondrial serine/threonine-protein kinase 1 (PINK1) can lead to the early onset of Parkinson’s Disease. It is conceivable that small molecules could be used to activate this protein and offer a protective effect against the disorder. One possible drug with such potential is Niclosamide and it has to be tested on further PD models to verify its potential effectiveness in treating the condition.
Viral Infections
Breathing in or consuming a virus can lead to an infection in a person. It’s possible that insect stings or sexual contact could be a means of transmission of the sickness. Viruses are capable of impacting the upper respiratory system, mouth and nose regions, digestive organs, neurological pathways, and reproductive matters. Antiviral medications are commonly employed to inhibit spread of viruses and upholding a robust immune system. Potentially, there could be an application of Niclosamide’s antiviral properties – as it has the ability to target host pathways which could result in reducing the seriousness of illness in some instances. Clinical tests have implemented Niclosamide to treat COVID 19, Ebola and Zika viruses thus far.
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Bacterial Infections
When a bacterium enters the body, it leads to an infection and provokes a lot of responses in the body. It can be conveyed through a cut or respiratory passages. Certain bacterial maladies have showcased the antibacterial effects of Niclosamide powder. Anthrax, TB, and MRSA are the most usual risks. The data imply that the medication is as successful as vancomycin, which is currently used to cure MRSA contagions.
Cancer
Experts have put great effort into researching cancer, and the findings that Niclosamide could effectively combat several forms of tumors such as oral, colon, lung, ovarian, breast, prostate, glioblastoma, osteosarcoma, leukemia, and adrenocortical carcinoma has been highlighted. Studies show that the anti-cancer properties of the drug let it harm tumor cell mitochondria, reduce tumor cell expansion, and cause apoptosis. Due to this, it could be a viable option compared to conventional cancer treatments.
Summary
Niclosamide capsules have numerous uses in the medical field, but like all drugs there are potential side effects that must be monitored. Research is needed to totally evaluate its uses and safety. An inadequate amount of information is currently available to properly grasp its abilities and effectiveness, so it is necessary to continue researching it in order to understand its potential for various therapeutic treatments.
